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Witte Lab
Departments of Epidemiology & Biostatistics, and Urology
University of California, San Francisco
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Last updated: September 11, 2003
© 2002
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Multilevel
Modeling in Epidemiology with GLIMMIX
This page gives SAS code and a Macro for epidemiologic analysis by
hierarchical modeling with the SAS Macro GLIMMIX. This site complements
the manuscript "Multilevel Modeling in Epidemiology with GLIMMIX" by
Witte et al. (Epidemiology 2000;11:684-688). In particular, we provide
an electronic version of the SAS code given in the
paper's appendix, and a Macro that automates some of the steps required when
using GLIMMIX.
To run the Macro, one inputs first- and second-stage data, plus if semi-Bayes,
pre-specified second-stage variance values. As currently written,
the Macro reproduces the application given in the corresponding manuscript.
To replicate our hierarchical modeling application with this Macro, follow
these steps:
- First, click on the link Hmmacros.zip to begin
extracting the programs and data given in this zip file. Note: you may need
to download the PKZIP
Shareware if it is not presently loaded on your computer.
- Open this file from its current location. (If your computer automatically
saves this file to a disk, then click on the saved file.)
- In PKZIP, click "Extract," "Extract files..." and save
them to a floppy disk in your a: drive. This will save the following files
and data: hmmacro.sas; hm1.sas; the first-stage design matrix, X_dat;
disease status, Y_dat; the second-stage design matrix, Z_dat; the
second-stage variance values, tau_dat; the potential confounders, W_dat; and
GLIMMIX, glmm612.sas.
- Open SAS (on your own system), and run the program "hmmacro.sas".
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